Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
Identifieur interne : 005985 ( Main/Exploration ); précédent : 005984; suivant : 005986Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
Auteurs : Pipsa Saharinen [Finlande] ; Hanna Helotera [Finlande] ; Juho Miettinen [Finlande] ; Camilla Norrmen [Finlande] ; Gabriela D'Amico [Finlande] ; Michael Jeltsch [Finlande] ; Tobias Langenberg [Belgique] ; Wouter Vandevelde [Belgique] ; Annelii Ny [Belgique] ; Mieke Dewerchin [Belgique] ; Peter Carmeliet [Belgique] ; Kari Alitalo [Finlande]Source :
- Genes & Development [ 0890-9369 ] ; 2010.
Abstract
The Claudin-like protein of 24 kDa (CLP24) is a hypoxia-regulated transmembrane protein of unknown function. We show here that
Url:
DOI: 10.1101/gad.565010
PubMed: 20439428
PubMed Central: 2861186
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002E14
- to stream Pmc, to step Curation: 002E13
- to stream Pmc, to step Checkpoint: 003474
- to stream Ncbi, to step Merge: 003A87
- to stream Ncbi, to step Curation: 003A87
- to stream Ncbi, to step Checkpoint: 003A87
- to stream Main, to step Merge: 005A38
- to stream Main, to step Curation: 005985
Le document en format XML
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Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country 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FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="Langenberg, Tobias" sort="Langenberg, Tobias" uniqKey="Langenberg T" first="Tobias" last="Langenberg">Tobias Langenberg</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></titleStmt><publicationStmt><idno 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type="wicri:Area/Main/Curation">005985</idno><idno type="wicri:Area/Main/Exploration">005985</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development</title><author><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Virology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Helotera, Hanna" sort="Helotera, Hanna" uniqKey="Helotera H" first="Hanna" last="Helotera">Hanna Helotera</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="Miettinen, Juho" sort="Miettinen, Juho" uniqKey="Miettinen J" first="Juho" last="Miettinen">Juho Miettinen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmen">Camilla Norrmen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="D Amico, Gabriela" sort="D Amico, Gabriela" uniqKey="D Amico G" first="Gabriela" last="D'Amico">Gabriela D'Amico</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion></affiliation></author><author><name sortKey="Langenberg, Tobias" sort="Langenberg, Tobias" uniqKey="Langenberg T" first="Tobias" last="Langenberg">Tobias Langenberg</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name><affiliation wicri:level="3"><nlm:aff id="aff6">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), VIB, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center (VRC), K.U. Leuven, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="aff1">Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, University of Helsinki, Helsinki FIN-00014</wicri:regionArea><wicri:noRegion>Helsinki FIN-00014</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">Genes & Development</title><idno type="ISSN">0890-9369</idno><idno type="eISSN">1549-5477</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Claudin-like protein of 24 kDa (CLP24) is a hypoxia-regulated transmembrane protein of unknown function. We show here that <italic>clp24</italic> knockdown in <italic>Danio rerio</italic> and <italic>Xenopus laevis</italic> results in defective lymphatic development. Targeted disruption of <italic>Clp24</italic> in mice led to enlarged lymphatic vessels having an abnormal smooth muscle cell coating. We also show that the <italic>Clp24</italic><sup>−/−</sup> phenotype was further aggravated in the <italic>Vegfr2<sup>+/LacZ</sup></italic> or <italic>Vegfr3<sup>+/LacZ</sup></italic> backgrounds and that CLP24 interacts with vascular endothelial growth factor receptor-2 (VEGFR-2) and VEGFR-3 and attenuates the transcription factor CREB phosphorylation via these receptors. Our results indicate that CLP24 is a novel regulator of VEGFR-2 and VEGFR-3 signaling pathways and of normal lymphatic vessel structure.</p></div></front></TEI><affiliations><list><country><li>Belgique</li><li>Finlande</li></country><region><li>Province du Brabant flamand</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Louvain</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><region name="Uusimaa"><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name></region><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="D Amico, Gabriela" sort="D Amico, Gabriela" uniqKey="D Amico G" first="Gabriela" last="D'Amico">Gabriela D'Amico</name><name sortKey="D Amico, Gabriela" sort="D Amico, Gabriela" uniqKey="D Amico G" first="Gabriela" last="D'Amico">Gabriela D'Amico</name><name sortKey="D Amico, Gabriela" sort="D Amico, Gabriela" uniqKey="D Amico G" first="Gabriela" last="D'Amico">Gabriela D'Amico</name><name sortKey="D Amico, Gabriela" sort="D Amico, Gabriela" uniqKey="D Amico G" first="Gabriela" last="D'Amico">Gabriela D'Amico</name><name sortKey="Helotera, Hanna" sort="Helotera, Hanna" uniqKey="Helotera H" first="Hanna" last="Helotera">Hanna Helotera</name><name sortKey="Helotera, Hanna" sort="Helotera, Hanna" uniqKey="Helotera H" first="Hanna" last="Helotera">Hanna Helotera</name><name sortKey="Helotera, Hanna" sort="Helotera, Hanna" uniqKey="Helotera H" first="Hanna" last="Helotera">Hanna Helotera</name><name sortKey="Helotera, Hanna" sort="Helotera, Hanna" uniqKey="Helotera H" first="Hanna" last="Helotera">Hanna Helotera</name><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><name sortKey="Miettinen, Juho" sort="Miettinen, Juho" uniqKey="Miettinen J" first="Juho" last="Miettinen">Juho Miettinen</name><name sortKey="Miettinen, Juho" sort="Miettinen, Juho" uniqKey="Miettinen J" first="Juho" last="Miettinen">Juho Miettinen</name><name sortKey="Miettinen, Juho" sort="Miettinen, Juho" uniqKey="Miettinen J" first="Juho" last="Miettinen">Juho Miettinen</name><name sortKey="Miettinen, Juho" sort="Miettinen, Juho" uniqKey="Miettinen J" first="Juho" last="Miettinen">Juho Miettinen</name><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmen">Camilla Norrmen</name><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmen">Camilla Norrmen</name><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmen">Camilla Norrmen</name><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmen">Camilla Norrmen</name><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Langenberg, Tobias" sort="Langenberg, Tobias" uniqKey="Langenberg T" first="Tobias" last="Langenberg">Tobias Langenberg</name></region><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name><name sortKey="Langenberg, Tobias" sort="Langenberg, Tobias" uniqKey="Langenberg T" first="Tobias" last="Langenberg">Tobias Langenberg</name><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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